| 宫傲,王瀚生,王富森,等.利马前列素治疗腰椎管狭窄症单侧双通道内镜减压术后残余症状的有效性研究.骨科,2026,17(2): 112-116. |
| 利马前列素治疗腰椎管狭窄症单侧双通道内镜减压术后残余症状的有效性研究 |
| Efficacy of limaprost in treating residual symptoms after unilateral biportal endoscopic decompression for lumbar spinal stenosis |
| 投稿时间：2025-07-15 |
| DOI：10.3969/j.issn.1674-8573.2026.02.003 |
| CN KeyWords: 腰椎管狭窄症 利马前列素 单侧双通道内镜 残留症状 有效性 |
| EN KeyWords: Lumbar spinal stenosis Limaprost Unilateral biportal endoscopy Residual symptoms Efficacy |
| Fund Project:黑龙江省自然科学基金项目（LH2021H053） |
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| CN Abstract: |
| 目的 探讨利马前列素治疗腰椎管狭窄症（LSS）患者单侧双通道内镜（UBE）减压术后残留症状的有效性，并评估其对患者长期功能恢复的作用。方法 采用回顾性病例分析，纳入我科2024年1月至12月接受UBE治疗且术后存在残余症状的57例LSS患者，依据术后是否加用利马前列素片，分为观察组（29例）和对照组（28例）。比较两组术后2周、1个月、2个月、4个月的腰部及双下肢疼痛视觉模拟量表（VAS）评分、Oswestry功能障碍指数（ODI）、日本骨科协会（JOA）评估治疗分数、匹兹堡睡眠质量指数（PSQI）及欧洲五维生活质量量表（EQ-5D-3L）。结果 与对照组比较，观察组术后1、2、4个月的腰部VAS评分均显著降低，术后2周至4个月的双下肢VAS评分持续显著降低，术后4个月的ODI评分显著降低，术后1、2、4个月的JOA评分明显升高，术后2个月的EQ-5D-3L评分显著升高，差异均有统计学意义（P＜0.05）。结论 利马前列素可有效改善LSS患者UBE减压术后出现的残留症状，但仍需更大的样本量和更长时间的随访来进一步证实。 |
| EN Abstract: |
| Objective To explore the efficacy of limaprost in treating residual symptoms in patients with lumbar spinal stenosis (LSS) after unilateral biportal endoscopic (UBE) decompression, and to evaluate its role in patients' long-term functional recovery. Methods A retrospective case analysis was conducted, enrolling 57 LSS patients with residual symptoms after UBE treatment in our department from January to December 2024. According to whether limaprost tablets were administered postoperatively, the patients were divided into the observation group (29 cases) and the control group (28 cases). The Visual Analogue Scale (VAS) scores for the low back pain and lower extremities, Oswestry Disability Index (ODI), Japanese Orthopaedic Association (JOA) score, Pittsburgh Sleep Quality Index (PSQI), and EuroQol 5-Dimensions 3-Levels (EQ-5D-3L) quality of life scale data were compared between the two groups at 2nd week, 1st month, 2nd month, and 4th month after surgery. Results Compared with the control group, the low back pain VAS scores in the observation group were significantly lower at 1st, 2nd, 4th month after surgery, and the VAS scores for bilateral lower extremities remained significantly lower from 2nd week to 4th month postoperatively, the ODI at 4th month postoperatively was significantly lower, the JOA lumbar spine function scores were significantly higher at 1st, 2nd, 4th month postoperatively and the EQ-5D-3L score was higher at 2nd month postoperatively, with statistically significant differences (P＜0.05). Conclusion Limaprost can effectively improve residual symptoms in LSS patients after UBE decompression, but it needs to be further confirmed with larger sample sizes and longer follow-up periods. |
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