| 黄军刚,卫永鲲.鸡尾酒式混合镇痛剂中添加激素对全膝关节置换术后临床效果的影响.骨科,2022,13(3): 249-254. |
| 鸡尾酒式混合镇痛剂中添加激素对全膝关节置换术后临床效果的影响 |
| Effect of Cocktail Mix Analgesics with Hormone on Clinical Outcome after Total Knee Arthroplasty |
| 投稿时间：2021-10-31 |
| DOI：10.3969/j.issn.1674-8573.2022.03.011 |
| 中文关键词: 鸡尾酒式混合镇痛剂 类固醇激素 曲安奈德 关节成形术，置换，膝 静脉血栓栓塞症 |
| 英文关键词: Cocktail mix analgesics Steoid hormone Triamcinolone acetonide Arthroplasty, replacement, Knee Venous thromboembolism |
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| 中文摘要: |
| 目的 探讨鸡尾酒式混合镇痛剂中添加激素对全膝关节置换术（total knee arthroplasty，TKA）后临床效果的影响。方法 选择2019年1月至2020年12月接受首次单侧TKA的原发性膝关节骨性关节炎病人作为研究对象，设置激素组和对照组，分别给予含激素的鸡尾酒式混合镇痛剂或常规鸡尾酒式混合镇痛剂，比较两组病人术后静态及动态情况下的数字等级量表（numeric rating scale，NRS）疼痛评分、术后首次直腿抬高时间、膝关节最大屈曲度、术后并发症、白细胞计数（WBC）、C-反应蛋白（CRP）及D-二聚体水平。结果 术后第1、3、7天时，激素组静态及动态NRS评分显著低于对照组，膝关节最大屈曲度明显大于对照组，下地活动量显著多于对照组，WBC显著高于对照组，CRP及D-二聚体水平显著低于对照组；同时，激素组的首次直腿抬高时间明显早于对照组，静脉血栓栓塞症（venous thromboembolism，VTE）发生率显著低于对照组。上述指标进行组间比较，差异均有统计学意义（P＜0.05）。结论 含激素的鸡尾酒式混合镇痛剂可有效缓解TKA术后疼痛、减轻炎症反应、预防VTE形成及加速早期康复训练。 |
| 英文摘要: |
| Objective To explore the effect of Cocktail mix analgesics with hormone on clinical outcome after total knee arthroplasty (TKA). Methods Patients with primary knee osteoarthritis who underwent unilateral TKA for the first time from January 2019 to December 2020 were selected, and divided into hormone group given cocktail mix analgesics with hormone and control group given cocktail mix analgesics without hormone. The static and dynamic Numerical Rating Scale (NRS) score, the first straight leg raising time, maximum flexion degree of knee joint, complications, white blood cell (WBC) count, C-reactive protein (CRP) and D-dimer levels were compared between the two groups. Results On the 1st, 3rd and 7th day after operation, the static and dynamic NRS score was significantly lower, the maximum flexion degree of knee joint movement was significantly higher, the out-of-bed activity quantity was significantly higher, the WBC count was significantly greater, the levels of CRP and D-dimer were significantly lower in the hormone group than those in the control group. At the same time, the first straight leg raising time was significantly earlier and the incidence of venous thromboembolism (VTE) was significantly lower in the hormone group than those in the control group. The above indexes were compared between groups, and the differences were statistically significant (P＜0.05). Conclusion Adding hormone in cocktail mix analgesics can effectively relieve pain, reduce inflammatory response, prevent VTE formation and accelerate early rehabilitation training of postoperative TKA. |
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