| 彭松林,何同忠,陈欣,等.一种新型光交联的聚酯弹性体的制备及其性能研究.骨科,2020,11(5): 431-435. |
| 一种新型光交联的聚酯弹性体的制备及其性能研究 |
| Preparation and properties of a novel photo-crosslinked polyester elastomer |
| 投稿时间：2020-07-08 |
| DOI：10.3969/j.issn.1674-8573.2020.05.016 |
| 中文关键词: 聚酯弹性体 力学性能 生物相容性 药物载体 |
| 英文关键词: Polyester elastomer Mechanical property Biocompatibility Drug carriers |
| 基金项目:深圳市科创委项目（JCYJ20180305164659637，JCYJ20180305164544288，JSGG20180504170427135，SGLH20180625-141602256） |
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| 中文摘要: |
| 目的 制备一种生物相容性良好的光交联的聚酯弹性体材料，探究其力学性能以及细胞相容性。方法 通过熔融缩聚方法合成含有双键、可降解的亲疏水片段聚合物，并引入无机纳米颗粒制备有机-无机一体化的复合聚酯弹性体材料（聚辛二醇-柠檬酸-衣康酸）。利用核磁共振氢谱（Hydrogen-1 Nuclear Magnetic Resonance Spectrometry, H1-NMR）、力学分析仪、流变仪研究聚酯弹性体的结构、抗压以及粘弹性能。研究该弹性体对特立帕肽（PTH）的包载和释放，并研究其药物释放特性和体外生物相容性。结果 H1-NMR结果表明弹性体中含有双键，可以实现光交联固化，压缩模量约为23 MPa，且具有稳定的粘弹性能，其储能模量约为90 kPa。体外细胞实验表明，该材料具有良好的生物相容性，通过负载PTH药物，前期呈快速释放，随后减慢，总释放率达60%。结论 本研究制备的有机-无机复合弹性体具有优良的力学性能和良好的生物相容性可实现细胞在其表面生长，同时可作为某些药物的载体，有望成为一种良好的骨缺损修复支架材料。 |
| 英文摘要: |
| Objective To prepare a polyester elastomer with good biocompatibility, and study the mechanical properties and cell affinity. Methods The organic-inorganic composite elastomer material scaffold was first synthesized by melting polycondensation to prepare the biodegradable hydrophobic segment which had double bond and inorganic nanoparticles. Hydrogen-1 nuclear magnetic resonance spectrometry (H1-NMR), mechanical analyzer and rheometer were used to study the structure, compressive and viscoelastic properties of polyester elastomer. The inclusion and release of the elastomer to PTH, and its biocompatibility and drug release characteristics in vitro were studied. Results H1-NMR results showed that the elastomer contained double bonds, which endowed photo-crosslinking curing. The prepared polyester elastomer had a high compression modulus of about 23 MPa and stable viscoelastic energy as its energy storage modulus could reach about 90 kPa. In vitro cells experiment showed that the material had good biocompatibility. The PTH drug was loaded and released rapidly in the early stage, then slowed down, with a total release rate of 60%. Conclusion The organic-inorganic composite elastomer prepared in this study has excellent mechanical properties and good biocompatibility, which can realize the growth of cells on the surface, and can also be used as some drug carriers, and is expected to be a good scaffold material for bone defect repair. |
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