| 张艳,李莹,张雪松.血管内皮生长因子和骨形态发生蛋白-2在糖尿病病人骨组织内表达水平的研究.骨科,2019,10(6): 529-533. |
| 血管内皮生长因子和骨形态发生蛋白-2在糖尿病病人骨组织内表达水平的研究 |
| Expression of vascular endothelial growth factor and bone morphogenetic protein-2 in bone tissue of diabetic patients |
| 投稿时间：2019-03-11 |
| DOI：10.3969/j.issn.1674-8573.2019.06.009 |
| 中文关键词: 糖尿病 胫骨高位截骨术 血管内皮生长因子 骨形态发生蛋白-2 |
| 英文关键词: Diabetes High osteotomy Vascular endothelial growth factor Bone morphogenetic protein-2 |
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| 中文摘要: |
| 目的 探讨血管内皮生长因子（vascular endothelial growth factor, VEGF）、骨形态发生蛋白-2（bone morphogenetic protein-2, BMP-2）在糖尿病病人胫骨组织内的表达水平。方法 在胫骨高位截骨术中，分别获取糖尿病病人（8例）和非糖尿病病人（8例）术部骨组织，从骨组织中提取总蛋白及RNA，用Western blot、RT-PCR检测骨组织中VEGF、BMP-2的表达水平。结果 糖尿病病人骨组织中VEGF、BMP-2蛋白和mRNA表达水平均明显低于非糖尿病病人。结论 糖尿病病人骨组织中VEGF、BMP-2因子表达低于正常水平，VEGF、BMP-2因子可能是影响糖尿病病人骨质及骨愈合的重要因素之一。 |
| 英文摘要: |
| Objective To investigate the expression levels of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) in the tibia of diabetic patients. Methods In the high osteotomy of the humerus, the bone tissues of diabetic patients (8 cases) and non-diabetic patients (8 cases) were obtained respectively. Total protein and RNA were extracted from bone tissue, and VEGF and BMP-2 in total bone tissue were detected by Western blot/RT-PCR. Results The expression levels of VEGF, BMP-2 mRNA and protein in bone tissue of diabetic patients were significantly lower than those in non-diabetic patients. Conclusion The expression of VEGF and BMP-2 in bone tissue of diabetic patients is lower than normal level. VEGF and BMP-2 may be one of the important factors affecting bone and bone healing in diabetic patients. |
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