| 石宇,党晓谦.重组人酸性成纤维细胞生长因子联合负压引流修复骨折并发慢性骨髓炎感染缺损创面的疗效研究.骨科,2017,8(5): 379-382. |
| 重组人酸性成纤维细胞生长因子联合负压引流修复骨折并发慢性骨髓炎感染缺损创面的疗效研究 |
| Repairing effect of recombinant acidic fibroblast growth factor combined with vacuum drainage in fracture complicated with infection defects of chronic osteomyelitis |
| 投稿时间：2017-03-15 |
| DOI：10.3969/j.issn.1674-8573.2017.05.009 |
| 中文关键词: 重组人酸性成纤维细胞生长因子 负压引流 骨折 慢性骨髓炎 |
| 英文关键词: Recombinant human acidic fibroblast growth factor Negative pressure drainage Fracture Chronic osteomyelitis |
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| 中文摘要: |
| 目的 探讨重组人酸性成纤维细胞生长因子（rh-aFGF）联合负压引流治疗骨折并发慢性骨髓炎感染缺损创面的疗效。方法 2014年1月至2016年6月在我院进行治疗的骨折并发慢性骨髓炎感染出现缺损创面的病人141例，按照随机数字表分为三组，每组47例，联合组给予负压引流清创+rh-aFGF治疗，rh-aFGF组清创后给予rh-aFGF治疗，对照组在清创后给予常规药物治疗。观察比较三组病人的伤腔容积好转率、外露骨组织愈合率、缺损创面细菌计数及缺损创面恢复情况。结果 三组伤腔容积好转率、外露骨组织愈合率逐渐增加，且三组同一时间点的各指标差异均具有统计学意义（P均＜0.05），联合组的结果均优于其他两组；治疗第2、3周，联合组的缺损创面细菌计数分别为（1.01±0.53）×104/cm2、（1.95±0.44）×104/cm2，rh-FaF组为（8.17±0.78）×104/cm2、（11.83±0.86）×104/cm2，对照组为（10.96±0.64）×104/cm2、（15.02±1.31）×104/cm2，三组同一时间点的数值比较，差异均具有统计学意义（F=8.922，10.736；P均＜0.05），且联合组的细菌计数均少于其他两组。结论 rh-aFGF联合负压引流在骨折并发慢性骨髓炎感染缺损创面的治疗中效果较好，显著促进创面愈合，改善治疗预后。 |
| 英文摘要: |
| Objective To investigate the effect of recombinant acid fibroblast growth factor (rh-aFGF) combined with negative pressure drainage in the treatment of fractures complicated with infection defects of chronic osteomyelitis. Methods A total of 141 cases of fractures complicated with infection defects of chronic osteomyelitis were divided into three groups (47 cases each) according to the principle of random number table. Combined group was given negative pressure drainage debridement+rh-aFGF treatment, rh-aFGF group was given rh-aFGF treatment after debridement, and control group was given routine medical treatment after debridement. Improvement rate of traumatic cavity volume, healing rate of the exposed bone, bacterial counts and the recovery status of defect wounds were observed and recorded. Results The improvement rate of traumatic cavity volume and healing rate of the exposed bone in the three groups were gradually increased, and the differences of indicators among three groups at the same time were statistically significant (P＜0.05 for all). The efficacy of the combined group was better than that in the rest two groups. The bacterial counts 2 and 3 weeks after treatment were 1.01±0.53 and 1.95±0.44 (combined group), 8.17±0.78 and 11.83±0.86 (rh-aFGF group), and 10.96±0.64 and 15.02±1.31 (control group) respectively, with the differences being statistically significant among the three groups at the same time point (F=8.922, 10.736; P＜0.05 for all), and the bacterial counts in the combined group were the lowest. Conclusion In the treatment of fracture with infection defects of chronic osteomyelitis, rh-aFGF combined with negative pressure drainage is effective, significantly promote wound healing, and improve the prognosis of treatment. |
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