| 戴繁林,熊敏,张鹏,等.全膝关节置换术中氨甲环酸局部不同给药方式控制术后出血的效果评价.骨科,2015,6(6): 298-301. |
| 全膝关节置换术中氨甲环酸局部不同给药方式控制术后出血的效果评价 |
| Efficacy of different local applications of tranexamic acid to control blood loss in total knee arthroplasty |
| 投稿时间：2015-06-15 |
| DOI：10.3969/j.issn.1674-8573.2015.06.005 |
| 中文关键词: 关节成形术，置换，膝 氨甲环酸 局部注射治疗 失血，手术 |
| 英文关键词: Arthroplasty, replacement, knee Tranexamic acid Local injection Blood loss, surgical |
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| 中文摘要: |
| 目的 前瞻性研究初次全膝关节置换术（total knee arthroplasty，TKA）中，氨甲环酸（tranexamic acid，TXA）注射液局部不同给药方式对术后出血的控制情况。方法 2012年4月至2014年11月间行单侧初次TKA的患者共计80例，年龄55.0～78.0岁，以抽取密闭信封的方式随机等分为两组，术中采取不同的局部给药方式：试验组（40例，行TXA关节周围注射）和对照组（40例，行传统关节腔灌洗处理）。观察两组TKA术后术腔引流量的差异性，对比两组术后24 h血红蛋白（hemoglobin，Hb）和红细胞压积（hematocrit，HCT）指标的差异性。结果 两组术前Hb及HCT差异均无统计学意义（均P>0.05），两组术后术腔引流量差异有统计学意义（P<0.05），术后24 h Hb及HCT复查结果差异有统计学意义（P<0.05）。结论 TKA术中TXA关节周围注射的止血效果优于关节腔灌洗的局部给药方式。 |
| 英文摘要: |
| Objective To prospectively observe the efficiency of blood loss control by different local administration of tranexamic acid in total knee arthroplasty (TKA). Methods Eighty patients treated with TKA of unilateral knee from Apr. 2012 to Nov. 2014 with the age ranging from 55.0 to 78.0 years old, were divided into 2 groups at random equally: the experimental group and control group. Intraoperatively 2 different local administrations of TXA were performed on the 2 groups to observe the therapeutic effect: experimental group (the periarticular injection), and control group (intra-articular lavage). The postoperative blood loss was compared between two groups, and the reduction of Hb and HCT was observed perioperatively. Results There was significant difference in the drainage volume between the two groups (P<0.05), and the difference in postoperative Hb and HCT was also significant (P<0.05). Conclusion Periarticular injection of TXA was more efficient to control blood loss than intra-articular lavage. |
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