| 钱文彬,杨欣建,陈扬,等.抗骨质疏松治疗的最佳他汀类药物及剂量选择的动物实验研究.骨科,2015,6(2): 57-61. |
| 抗骨质疏松治疗的最佳他汀类药物及剂量选择的动物实验研究 |
| Animal experiments of optimal statins drugs and doses of anti-osteoporosis treatment |
| 投稿时间：2014-11-25 |
| DOI：10.3969/j.issn.1674-8573.2015.02.001 |
| 中文关键词: 骨质疏松 他汀类药物 双膦酸盐 骨密度 |
| 英文关键词: Osteoporosis Statins Biphosphonates Bone mineral density |
| 基金项目:广东省中医药局建设中医药强省科研课题资助项目（No.20141257）；深圳市未来产业发展专项资金资助项目（No.CXZZ20140414170821148） |
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| 中文摘要: |
| 目的 探索具有最佳抗骨质疏松作用的他汀药物种类和药物剂量，为进一步研究他汀药物同时发挥抗骨质疏松和调脂作用提供基础。方法 40只12月龄新西兰白兔通过双侧卵巢切除和泼尼松龙诱导8周建立骨质疏松症模型，随机分为四组：生理盐水（normal saline, NS）组，瑞舒伐他汀（rosuvastatin, RSV）组，辛伐他汀（simvastatin, Sim）组，阿仑膦酸钠片（Alendronate, ALN）组。RSV组和Sim组按药物浓度梯度分为五个小组。定期测量白兔股骨骨密度（bone mineral desity, BMD）和骨钙素（bone gamma-carboxyglutamic-acid-containing proteins, BGP）、抗酒石酸酸性磷酸酶5b（tartrate-resistant acid phosphatase 5b, TRACP-5b）值。结果 8周末BMD较0周时明显降低（P＜0.05）。12、24和36周末，RSV组、Sim组和ALN组比NS组BMD、BGP水平明显升高，TRACP-5b水平显著降低（P＜0.01），并且RSV组与ALN组指标接近（P＞0.05）。RSV组内中以60 mg/（kg·d）喂养时，BMD、BGP较其他组明显升高。结论 他汀类药物具有抗骨质疏松的作用，效果接近唑来膦酸；亲水性瑞舒伐他汀比疏水性他汀药物作用更佳；并且剂量在60 mg/（kg·d）时效果更好。 |
| 英文摘要: |
| Objective To explore the specie and dose of statin who has the best anti-osteoporotic effects, providing the foundation for further study of statins playing the role of anti-osteoporosis and regulating blood lipids. Methods 40 12-month-old New Zealand white rabbits by bilateral ovariectomy and prednisolone-induced for 8 weeks are randomly divided into four groups: normal saline group (NS), rosuvastatin group (RSV), simvastatin group (Sim), Alendronate group (ALN). RSV and Sim are divided into five groups by the dose gradient 20, 40, 60, 80 and 100 mg/（kg·d）. White rabbit femur bone mineral density (BMD), bone gamma-carboxyglutamic-acid-containing proteins (BGP) and tartrate-resistant acid phosphatase 5b (TRACP-5b) are measured at the 0, 8th,12th, 24th, 36th weekends. Results Compared with 0 weekend, the rabbits BMD significantly reduced at 8th weekend (P<0.05). Comparing RSV, Sim and ALN to NS, the BMD and BGP levels are significantly increased, TRACP-5b level are significantly reductive (P<0.01), and RSV group and ALN datas are close (P>0.05). In the RSV groups feeded by 60 mg/（kg·d）, BMD and BGP are significantly higher than other groups after 12 weeks. Conclusion Statins have anti-osteoporosis effects，closing to zoledronic acid; hydrophilic statin rosuvastatin is more effective than the hydrophobic; and has better results at the dose 60 mg/（kg·d）. |
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