| 管频,陈娟,冯光球,等.慢性阻塞性肺疾病合并骨质疏松时肿瘤坏死因子α、白细胞介素6的表达及意义.骨科,2014,5(3): 133-135,142. |
| 慢性阻塞性肺疾病合并骨质疏松时肿瘤坏死因子α、白细胞介素6的表达及意义 |
| Relationship of bone density with inflammatory factors such as TNF-α and IL-6 in chronic obstructive pulmonary diseases |
| 投稿时间：2014-04-28 |
| DOI：10.3969/j.issn.1674-8573.2014.03.002 |
| 中文关键词: 肺疾病，慢性阻塞性 骨质疏松 肿瘤坏死因子α 白细胞介素6 骨密度 |
| 英文关键词: Pulmonary disease, chronic obstructive Osteoporosis Tumor necrosis factor-alpha Interleukin-6 Bone density |
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| 中文摘要: |
| 目的 观察慢性阻塞性肺疾病（chronic obstructive pulmonary diseases, COPD）患者骨密度（BMD）的变化与血清炎性细胞因子肿瘤坏死因子α(TNF-α)、白细胞介素6（IL-6）的关系。方法 选取稳定期COPD患者72例（COPD组），另选匹配正常对照组60例，所有对象均测定腰椎(L2～4)的BMD、肺功能，并测定所有入选对象的血钙、血磷、血清碱性磷酸酶(ALP)、TNF-α、IL-6、骨钙素及尿吡啶啉/肌酐。结果 COPD组与对照组比较血钙、血磷、ALP差异均无统计学意义(P＞0.05)；COPD组BMD及骨钙素较对照组低，差异有统计学意义(P＜0.05或P＜0.01)，且COPD组血清TNF-α、IL-6及尿吡啶啉/肌酐较对照组高，差异有统计学意义(P＜0.05或P＜0.01)。COPD患者的血清TNF-α、IL-6水平分别与BMD及骨钙素均呈负相关(均P＜0.05)，与尿吡啶啉/肌酐呈正相关(r=0.457，P＜0.05)，而与血钙、血磷、ALP无相关性(P＞0.05)。结论 COPD患者骨吸收增加、BMD减低与炎症因子TNF-α、IL-6的增高相关，COPD的全身炎症反应可能促进骨质疏松的发生。 |
| 英文摘要: |
| Objective To investigate the bone mineral density (BMD) in patients with chronic obstructive pulmonary diseases (COPD) and its relationship with some inflammatory factors such as TNF-α and IL-6. Methods Seventy-two cases of stable COPD and 60 healthy controls were included in this study. Pulmonary function and BMD were measured in all subjects. Serum calcium, serum phosphorus, alkaline phosphatase (ALP), osteocalcin (OC), TNF-α, IL-6 and urinary PYD/creatinine were tested in all subjects. Results There was no significant difference in the levels of serum calcium, serum phosphorus and ALP between the COPD group and the control group (P>0.05). The serum TNF-α and IL-6 levels in the COPD group were significantly higher than in the control group (P<0.05). The BMD in the COPD group was reduced as compared with the control group (P<0.05). The levels of TNF-α and IL-6 in serum were negatively related to the BMD and OC (P<0.05), but positively to the urinary PYD/creatinine (P<0.05). Conclusion Inflammatory factors such as TNF-α and IL-6 may promote bone resorption and suppress bone formation, which is related to osteopenia in COPD. Systemic inflammatory response in COPD may aggravate the osteoporosis. |
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